MSRedux Apps for IonSense DART source
BioAnalyte has partnered with IonSense of Saugus, MA, to develop data reduction and analysis software for the DART source, which couples to most major mass spectrometers.
IonSense provides interfaces to enable Direct Analysis in Real Time on existing LC/MS, and sells instruments that enable automated sample handling. The AutoDART-96™, for example, provides the capability to automate repetitive analysis of many samples.
As the DART advances its performance specifications in speed, sensitivity and throughput, BioAnalyte will develop custom applications to guarantee that these improvements will be available to the DART users.
- MSRedux-MIM "Microtiter Ion Monitor"
MIM creates figures for the serial analysis of 96 injections of sample into the DART source, followed by analysis by an Agilent or Thermo ion trap. Ion abundances are reported for each well. Complete Description is here.
- MSRedux-SA "Specific Activity"
SA calculates the concentration of a small molecule based on a comparison of a reference mass spectrum, and isotopically-labeled spectrum, and liquid scintillation data.
- MSRedux-XI "Extracted Ion"
XI creates TIC, XIC and summed scan plots for an ABI ion trap. The input is the sample data and a chemical formula for the species of interest. The output includes flagging for found/not found as well as DART source temperature and other GLP parameters.
BioAnalyte supports all of the vendor file formats relevant in the DART application world:
- JEOL AccuTOF™
- ABI/MDS API-400 Linear Ion Trap & Triple Quads
- AGILENT LC/MS Ion Trap, LC/MS 1100
- BRUKER Esquire Ion Traps
- THERMO LTQ Ion Trap, Orbitrap, Quantum, Triple Quadrupole
- THERMO Classic DECA, DECA XP, XP+
- WATERS Premier Triple Quad, Single Quadrupole, Fishbowl Source